Laboratory Studies in Glaucoma

David Epstein, MD
Massachusetts Eye and Ear Infirmary (Boston, MA)
Year Awarded:
1988
Grant Duration:
April 1, 1988 to March 31, 1989
Disease:
Glaucoma
Award Amount:
$93,600
Grant Reference ID:
G1988036
Award Type:
Standard
Award Region:
US Northeastern

Laboratory Studies in Glaucoma

Summary

Publications

O'Brien, E.T., Perkins, S.L., Roberts, B.C., and Epstein, D.L. (1996) Dexamethasone inhibits trabecular cell retraction. Exp. Eye Res. 62:675-688.  

Threlkeld, A.B., Allingham, R.R., Sturm, R., and Epstein, D.L. (1996) A comparative study of argon laser trabeculoplasty for exfoliation and primary open angle glaucoma. J. Glaucoma. 5:311-316.  

Russell, P., Koretz, J., and Epstein, D.L. (1993) Is primary open angle glaucoma caused by small proteins? Med. Hypotheses. 41:455-458.  

[Book Chapter] Epstein, D.L., de Kater, A.W., Erickson-Lamy, K.A., Fay, F.S., et al. The search. for a sulfhydryl drug for glaucoma: From chemistry to the cytoskeleton. In: Basic Aspects of Glaucoma Research. 111, Lutjen-Drecoll, E., ed., Schattauer, Stuttgart-New York 1993, pp. 345-353. de Kater, A.W., Shahsafaei, A., and Epstein, D.L. (1992) Localization of smooth muscle and non-muscle actin isoforms in the human aqueous outflow pathway. Invest. Ophthalmol. Vis. Sci. 33:424-429.  

Allingham, R.R., de Kater, A.W., Ethier, C.R., Anderson, P.J., et al. (1992) The relationship between pore density and outflow facility in human eyes. Invest. Ophthalmol. Vis. Sci. 33:1661-1669.  

Liang, L.L., Epstein, D.L., de Kater, A.W., Shahsafaei, A., et al. (1992) Ethacrynic acid increases facility of outflow in the human eye in vitro. Arch. Ophthalmol. 110:106-109.  

Tingey, D.P., Schroeder, A., Epstein, M.P.M., and Epstein, D.L. (1992) Effects of topical ethacrynic acid adducts on intraocular pressure in rabbits and monkeys. Arch. Ophthalmol. 110:699-702.  

Epstein, D.L., Hooshmand, L.B., and Epstein, M.P.M. (1992) Thiol adducts of ethacrynic acid increase outflow facility in enucleated calf eyes. Curr. Eye Res. 11:253-258.  

Liang, L.L. and Epstein, D.L. (1992) Comparison of mitomycin C and 5-fluorouracil on filtration surgery success in rabbit eyes. J. Glaucoma. 12:87-93. [PMID:nd] [link not available] Erickson-Lamy, K.A., Schroeder, A., and Epstein, D.L. (1992) Ethacrynic acid induces reversible shape and cytoskeletal changes in cultured cells. Invest. Ophthalmol. Vis. Sci. 33:2631-2640.  

Xu, S., Roychowdhury, S., Gaskin, F., and Epstein, D.L. (1992) Ethacrynic acid inhibition of microtubule assembly in vitro. Arch. Biochemistry and Biophysics. 296:462-467.  

Russell, P. and Epstein, D.L. (1992) Protein analysis of monkey aqueous humor. Curr. Eye Res. 12:1239-1243.  

Tingey, D.P., Ozment, R.R., Schroeder, A., and Epstein, D.L. (1992) The Effect of intracameral ethacrynic acid on the intraocular pressure of living monkeys. Am. J. Ophthalmol. 113:706-711.  

Epstein, D.L. and Rohen, J.W. (1991) Morphology of the trabecular meshwork and inner-wall endothelium after canonized ferritin perfusion in the monkey eye. Invest. Ophthalmol. Vis. Sci. 32:160-171.  

Johnson, M., Chen, A., Epstein, D.L., and Kamm, R.D. (1991) The pressure and volume dependence of the rate of wash-out in the bovine eye. Curr. Eye Res. 10:373-375.  

Johnson, M., Johnson, D.H., Kamm, R.D., de Kater, A.W., and Epstein, D.L. (1990) The filtration characteristics of the aqueous outflow system. Curr. Eye Res. 50:407-418.  

Epstein, D.L., de Kater, A.W., Lou, M., and Patel, J. (1990) Influences of glutathione and sulfhydryl containing compounds on aqueous humor outflow function. Exp. Eye Res. 50:785-794.  

Erickson-Lamy, K.A., Epstein, D.L., Schroeder, A.M., and Bassett-Chu, S. (1990) Absence of time-dependent facility increase ('washout') in the perfused enucleated human eye. Invest. Ophthalmol. Vis. Sci. 31:2384-2388.  

de Kater, A.W., Melamed, S., and Epstein, D.L. (1989) Patterns of aqueous humor outflow in glaucomatous and nonglaucomatous human eyes. A tracer study using canonized ferritin. Arch. Ophthalmol. 107:572-576.  

Rosenquist, R.C., Epstein, D.L., Melamed, S., Johnson, M., and Grant, W.M. (1989) Outflow resistance of enucleated human eyes with two different perfusion pressures and different extents of trabeculotomy. Curr. Eye Res. 8:1233-1240.  

Pavao, A.F., Lee, D.A., Ethier, C.R., Johnson, M.C., et al. (1989) 2-Dimensional gel electrophoresis of calf aqueous humor, serum and filter-bound proteins. Invest. Ophthalmol. Vis. Sci. 30:731-738.  

Nguyen, K.P.V., Chung, M.L., Anderson, P.J., Johnson, M., and Epstein, D.L. (1988) Hydrogen peroxide removal by the calf aqueous outflow pathway. Invest. Ophthalmol. Vis. Sci. 29:976-978.  

Latina, M., Goode, S., de Kater, A.W., et al. (1988) Experimental ab interno sclerotomies using a pulsed-dye laser. Lasers Med. Surg. 8:233-240.  

Rosenquist, R.C., Melamed, S., and Epstein, D.L. (1988) Anterior and posterior axial lens displacement and human aqueous outflow facility. Invest. Ophthalmol. Vis. Sci. 29:1159-1164.  

Erickson-Lamy, K.A., Rohen, J.W., and Grant, W.M. (1988) Outflow facility studies in the perfused bovine aqueous outflow pathway. Curr. Eye Res. 7:799-807.  

Melamed, S. and Epstein, D.L. (1987) Alterations of aqueous humor outflow following argon laser trabeculoplasty in monkeys. Br. J. Ophthalmol. 71:776-781.  

Melamed, S., Latina, M.A., and Epstein, D.L. (1987) Neodyniium: YAG laser trabeculopuncture in juvenile open angle glaucoma. Ophthalmol. 94:160-170.  

[Book Chapter] Richter, C.U. and Epstein, D.L. Lens induced open angle glaucoma. In: The Glaucomas, R. Ritch, T. Krupin, and M.B. Shields, eds. C.V. Mosby, St. Louis, 1989, pp. 1017-1026. Johnson, M.C., Ethier, C.R., Kamm, R.D., Grant, W.M., et al. (1986) The flow of aqueous humor through micro-porous filters. Invest. Ophthalmol. Vis. Sci. 27:92-97.  

Epstein, D.L., Freddo, T.F., Anderson, P.J., Patterson, M.M., and Bassett-Chu, S. (1986) Experimental obstruction to aqueous outflow by pigment particles in living monkeys. Invest. Ophthalmol. Vis. Sci. 27:387-395.  

Melamed, S., Pei, J., and Epstein, D.L. (1986) Delayed response to argon laser trabeculoplasty in monkeys. Morphological and morphometric analysis. Arch. Ophthalmol. 104:1078-1083.  

Nguyen, K.P.V., Lee, D.A., Anderson, P.J., and Epstein, D.L. (1986) Glucose 6-phosphate dehydrogenase of calf trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 27:992-997.  

Melamed, S., Freddo, T.F., and Epstein, D.L. (1986) Use of cationized ferritin to trace aqueous humor outflow in the monkey eye. Exp. Eye Res. 43:273-278.  

Nguyen, K.P.V., Weiss, H., Karaguezian, L.M., Anderson, P.J., and Epstein, D.L. (1985) Glutathione reductase of calf trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 26:887-890.  

Melamed, S., Pei, J., Puliafito, C.A., and Epstein, D.L. (1985) Q-Switched neodymium-YAG laser trabeculopuncture in monkeys. Arch. Ophthalmol. 103:129-133.  

Freedman, S.F., Anderson, P.J., and Epstein, D.L. (1985) Superoxide dismutase and catalase of calf trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 26:1330-1335.  

Melamed, S., Pei, J., and Epstein, D.L. (1985) Short-term effect of argon laser trabeculoplasty in monkeys. Arch. Ophthalmol. 103:1546-1552.  

Epstein, D.L., Melamed, S., Puliafto, C.A., and Steinert, R.F. (1985) Neodymium-YAG laser trabeculopuncture in open angle glaucoma. Ophthalmol. 92:931-937.  

 

Anderson, P.J., Karageuzian, L.N., Cheng, H.M., and Epstein, D.L. (1984) Hexokinase of calf trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 25:1258-1261.  

Anderson, P.J., Karageuzian, L.N., and Epstein, D.L. (1984) Phosphofructokinase of calf trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 25:1262-1266.  

Latina, M.A., Puliafito, C.A., Steinert, R.R., and Epstein, D.L. (1984) Experimental iridotomy with the Q-switched neodymium-YAG laser. Arch. Ophthalmol. 102:1211-1213.  

Scott, D.R., Karageuzian, L.N., Anderson, P.J., and Epstein, D.L. (1984) Glutathione peroxidase of calf trabecular meshwork. Invest. Ophthalmol. Vis. Sci. 25:599-602.  

[Book Chapter] Epstein, D.L. and Anderson, P.J. The Biochemistry of Outflow Mechanisms. In: Applied Pharmacology in the Medical Treatment of Glaucomas. S. M. Drance, ed. 1984, pp. 135-150.

Don't miss out.
Receive research updates, inspiring stories, and expert advice
Please enter your first name.
Please enter your last name.
Keep me informed about: *
Please select at least one.
You must select at least one disease category.