In Search of Genetic Causes for Glaucoma in African Populations

Caroline Klaver, MD, PhD
Erasmus Medical Center (Rotterdam, Netherlands)

Co-Principal Investigators

Cornelia M. van Duijn
Erasmus Medical Center (Rotterdam, Netherlands)
Year Awarded:
2015
Grant Duration:
July 1, 2015 to June 30, 2017
Disease:
Glaucoma
Award Amount:
$100,000
Grant Reference ID:
G2015084
Award Type:
Standard
Award Region:
International
Caroline Klaver, MD, PhD

Genetics in Glaucoma Patients of African Descent, the GIGA Study

Summary

Glaucoma is a leading cause of blindness in the world, and is particularly prevalent among persons of African descent. Genetic studies are currently investigating the causes for this disease, but have thus far only been performed in persons of European and Asian descent. With this project, we aim to find the genetic causes for glaucoma in African populations. This will help us understand why glaucoma is so common in Africa, provide us with knowledge on the causes of glaucoma, and help create means to cure and prevent this disease.

Details

Primary open angle glaucoma (POAG) is most common form of glaucoma, and its causes are still largely unknown. Family history and ethnicity are important risk factors, supporting a genetic basis for this disease. In the past years, my research group in Rotterdam has made substantial contributions to the discovery of > 25 genes for POAG, glaucomatous optic nerve, and eye pressure. Unfortunately, these genes explain only a small fraction of POAG cases, leaving a large part of the disease background unclear.

Mostly European and Asian populations were enrolled in the genetic studies. Considering their prevalence and severity of POAG, African populations are a better choice. The prevalence of POAG is three to five times higher in Africans, and the disease has a much more dramatic course with a higher risk of blindness. We believe that these characteristics will facilitate the identification of new genetic risk factors for POAG, and lead the way to important disease pathways.

In collaboration with hospitals from Tanzania and South Africa, we collected a total of 1,500 POAG cases and unaffected controls of African descent. We aim to identify new genetic causes of POAG using genome-wide exome array analysis. Since identification of novel genes will require very large study samples, we will form a consortium with other studies of Africans and analyze our genetic findings jointly. This strategy will help reveal the genetic causes of POAG, and may open up new avenues for therapy and prevention.      

About the Researcher

Caroline Klaver, MD, PhD, is an ophthalmologist/epidemiologist and professor of Epidemiology and Genetics of Eye Disorders at Erasmus MC (University Medical Center), Erasmus University Rotterdam, The Netherlands. She received her MD and PhD degrees at the Erasmus University Rotterdam and completed her postdoctoral training at Iowa University, Iowa City, Iowa;  Columbia University, New York City; and with Vitreous-Retina-Macula Consultants of New York in the field of ophthalmogenetics. 

Her primary focus has been genetic-epidemiologic studies of complex and Mendelian eye disorders. She is the principal investigator of the ophthalmologic studies in eight large epidemiologic cohorts from Rotterdam (total N=27,000 study participants), and a collaborator with many international studies (total N=300,000 study participants). Her focus of research is epidemiology, genetic epidemiology, gene-finding, prediction modelling, environmental factors, gene-environment interaction, and clinical translation of research findings.

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