Functions of Optineurin, a Glaucoma Gene

Beatrice Yue, PhD
University of Illinois at Chicago (Chicago, IL)
Year Awarded:
2008
Grant Duration:
April 1, 2008 to March 31, 2010
Disease:
Glaucoma
Award Amount:
$100,000
Grant Reference ID:
G2008024
Award Type:
Standard
Award Region:
US Midwestern

Functional Roles of Optineurin in RGC-5 cells

Summary

This study examines how proteins are transported inside cells and how neurites grow. The study may enhance understanding of mechanisms leading to neuronal cell loss in glaucoma and facilitate development of new treatments for glaucoma.

Details


The researchers will study the roles of optineurin, a glaucoma gene, in two cellular functions in neuronal cells. One functions relates to the transportation of proteins inside cells, and the other governs whether and how neurites extend or grow in the cells. This study will provide new information about the role of optineurin in these important functions. It should also help explain why and how abnormal levels or mutations of optineurin may lead to glaucoma. The study may enhance understanding of mechanisms leading to neuronal cell loss in glaucoma and facilitate development of new treatments for glaucoma.

Publications

Koga, T., Shen, X., Park, J., Qiu, Y., Park, B.C., Shyam, R. and Yue, B.Y.J.T. (2010) Differential Effects of Myocilin and Optineurin, Two Glaucoma Genes, on Neurite Outgrowth. Am. J. Pathol. 176, 343-352  

Ying, H., Shen, X., Park, B.C. and Yue, B.Y.J.T. (2010) Posttranslational modification, localization and protein protein interactions of optineurin. PLoS One 5:e9168.  

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