Project DetailsWe have recently identified the Bestrophin-2 protein (Best2) as a key regulator of fluid dynamics in the eye. This study will determine, via two specific aims, the mechanisms underlying this unique activity. If successful, this study will lead to new therapeutic options for treatment of glaucoma. Specific aims are 1. To determine how Best2 functions to antagonize the formation of aqueous humor, the fluid found in the eye. 2. To determine how absence of Best2 enhances outflow of aqueous humor from the eye.