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Our research focuses on the trabecular meshwork (TM), a spongy tissue located in the eye around the base of the cornea, near the ciliary body. The TM is responsible for draining a fluid called aqueous humor from the eye via the anterior chamber, and is believed to be the tissue that regulates intraocular pressure, a critical factor in the development of glaucoma. Our laboratory is investigating the hypothesis that a specific subset of complex molecules that reside in the TM, and that interact with each other, are important in the regulation of aqueous humor outflow resistance. When these processes are disrupted, there will be changes in the tissue that lead to alterations in outflow facility. Thus our primary objective is to improve the overall understanding of how aqueous humor outflow resistance is regulated and to determine the triggers of glaucoma in order to hasten the development of new therapies that help glaucoma patients.