Eitan Wong, PhD
Dr. Eitan Wong received his PhD in 2014 from the Weizmann Institute of Science, Israel. Under the supervision of Dr. Irit Sagi of the Biological Regulation Department, Dr. Wong focused on Metalloprotease regulation and inhibition, acquiring extensive experience and understanding of the regulation of the protease network. In 2015, Dr. Wong joined the laboratory of Dr. Yueming Li at The Pharmacology and Chemical Biology department of the Memorial Sloan Kettering Cancer Center (MSKCC), New York. As a post-doctoral fellow at MSKCC, Dr. Wong. is conducting research to understand the molecular mechanism of Alzheimer’s disease, emphasizing the role of proteolytic activity. At MSKCC, Dr. Wong is exposed to world-class leaders in neuroscience and neurodegeneration, learning the cutting-edge scientific methodology and current ideas. Due to a fruitful collaboration with the late Dr. Paul Greengard (Rockefeller University) a Nobel Laureate and a pioneer in the field of Alzheimer’s and neurodegenerative disease, Dr. Wong was able to prove the existence of specific protease modulator that can directly influence Aβ plaque formation in Alzheimer’s disease. In addition, during Dr. Wong’s work at MSKCC, he discovered that γ-secretase activity appears to fluctuate depending on time of the day, suggesting a circadian rhythm regulation. As a biochemist with extensive experience in molecular and cellular protease regulation, Dr. Wong is well positioned to decipher the underlying mechanism of circadian regulation of protease activity and it effect on the pathogenesis of Alzheimer’s disease.