Dominik Paquet, PhD

Dr. Dominik Paquet received his PhD in 2009 from the Ludwig-Maximilians-University (LMU) in Munich, Germany, where he successfully developed the first transgenic zebrafish model of Tauopathies and demonstrated its suitability for in vivo drug screening and real-time in vivo imaging of disease processes. During his postdoctoral work with Marc Tessier-Lavigne at The Rockefeller University in New York City, which was supported by the German Academy of Sciences Leopoldina and The New York Stem Cell Foundation, Dr. Paquet entered the novel field of induced pluripotent stem cell (iPSC) based disease modeling. He built up a new iPSC laboratory at Rockefeller and developed efficient technologies to edit the genome of iPSCs by CRISPR/Cas9 editing to study Alzheimer’s and other neurodegenerative diseases in human brain cells. As a New York Stem Cell Foundation Druckenmiller Fellow, he was embedded in a thriving network of top-notch stem cell scientists, which allowed him to gain profound knowledge of related fields of stem cell research and strong ties with the stem cell community. Dr. Paquet established the PaquetLab ( at the Institute for Stroke and Dementia Research (ISD) of LMU Munich in 2017 and currently serves as Professor of Neurobiology and core member of Synergy (, a leading Research Cluster of the Excellence Initiative of the German research funding organization. Using his broad background in neurodegenerative disease research, with specific training and expertise in molecular, stem cell and neurobiology, he leads an interdisciplinary team of neurobiologists, biochemists and stem cell biologists. The PaquetLab uses cutting-edge technologies such as CRISPR genome editing, iPSC differentiation and human 3D tissue engineering to elucidate the molecular function of the human brain and the mechanisms leading to neurodegenerative and neurovascular diseases.