Dominik Paquet, PhD

Dr. Dominik Paquet received his PhD in 2009 from the University of Munich. During his postdoctoral work with Marc Tessier-Lavigne at The Rockefeller University, which was supported by the German Academy of Sciences Leopoldina and The New York Stem Cell Foundation, he built up a new iPSC laboratory at Rockefeller and developed efficient technologies to edit the genome of iPSCs by CRISPR/Cas9 editing to study neurodegenerative diseases in human brain cells. As a NYSCF Druckenmiller Fellow, he was embedded in a thriving network of top-notch stem cell scientists, which allowed him to gain profound knowledge of stem cell research and strong ties with the community. Dr. Paquet established the PaquetLab ( at the Institute for Stroke and Dementia Research of University of Munich in 2017 and currently serves as Professor of Neurobiology and core member of SyNergy (, a leading European neuroscience Research Center funded by the DFG Excellence Initiative. Using his broad background in neurodegenerative disease research, with specific training and expertise in molecular, stem cell and neurobiology, he leads an interdisciplinary team of neurobiologists, biochemists, and stem cell biologists. The PaquetLab uses cutting-edge technologies such as CRISPR, iPSC differentiation and human 3D tissue engineering to elucidate the molecular function of the human brain and the mechanisms leading to neurodegenerative and neurovascular diseases.