Testing For Calcium Dysregulation In A New AD Model
To further verify that our results are occurring due to a problem in synaptic dysfunction versus cell loss, we have tested the effect of treating the psn-het flies starting at day 30 (when deficits in learning and memory are observed) up until day 45 and re-testing their learning and memory. What we have found is that we can reverse the loss of learning and memory, restoring it to normal levels, as compared to control flies. This result further supports the idea that the cognitive deficits we are detecting in our model are more likely due to a defect in signaling, such as problems with the calcium (Ca2+) release, as we have proposed. These results have been included in a manuscript that has recently been published (McBride et al.,2010).
First published on: April 14, 2009
Last modified on: March 18, 2011