Project Details Inflammation of the brain has been reported to be associated with the development of Alzheimer's disease. Proteins called “Toll-like receptors” are critical components of the immune system that drives brain inflammation. Therefore, Dr. Paramita Chakrabarty and collaborators will express parts of Toll-like receptors in mice with Alzheimer's disease to sequester beta-amyloid protein and prevent brain plaque formation. The mice will be evaluated for changes in cognitive functions, beta-amyloid plaque formation, and the number of immune cells. This treatment is expected to reduce brain inflammation and thus prevent or reduce the severity of disease symptoms. Similar strategies of Toll-like receptor delivery have been used by researchers in cancer and arthritis research. Dr. Chakrabarty's research will help to clarify the role of immunity in Alzheimer's disease and could lead to the development of new therapeutic strategies.