Screen for Proteins Interacting with APP and its Homologues

Rudolph Tanzi, PhD
Massachusetts General Hospital (Charlestown, MA)
Year Awarded:
1995
Grant Duration:
April 1, 1995 to March 31, 1997
Disease:
Alzheimer's Disease
Award Amount:
$200,000
Grant Reference ID:
A1995038
Award Type:
Standard
Award Region:
US Northeastern

Screen for Proteins Interacting with APP and its Homologues

Details


Publications

[Book Chapter] Kim, T.W., Hallmark, O.G., Pettingell, W.H., Wasco, W., et al (1997) Proteolytic processing and ubiquitin-proteasomal degradation of wild-type and mutant forms of Presenilin 2. In: Alzheimer's Disease: Biology, Diagnosis, and Therapeutics . K. Iqbal, B. Winblad, T. Nishimura, M. Takeda, H.M. Wisniewski, eds. John Wiley and Sons Ltd, West Sussex, 1997, pp. 576-582.

Tanzi, R.E., Kovacs, D.M., Kim, T.W., Moir, R.D., et al. (1996) The gene defects responsible for familial Alzheimer's disease. Neurobiol. Dis. 3(3):159-168.  

Kovacs, D.M., Fausett, H.J., Page, K.J., Kim, T.W., et al. (1996) Alzheimer-associated Presenilins I and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nature Med. 2:224-230. [Alzforum Recommended Paper][Alzforum Milestone Paper]  

Scheuner, D., Eckman, C., Jensen, M., Song, X., et al. (1996) Secreted amyloid beta protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the Presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Medicine. 2:864-870. [Alzforum Recommended Paper][Alzforum Milestone Paper]  

Guenette, S.Y., Chen, J., Jondro, P.D., Tanzi, R.E. (1996) Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein. Proc. Natl. Acad. Sci. USA. 93:10832-10837.  

Bush, A.I., Moir, R.D., Rosenkranz, K.M., and Tanzi, R.E. (1995) Zinc and Alzheimer's disease. Science. 268:1920-1923.  

Kounnas, M.Z., Moir, R.D., Rebeck, G.W., Bush, A.I., et al. (1995) LDL receptor-related protein, a multifunctional apolipoprotein E receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell. 82:331-340.  

Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D.M., et al. (1995) Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science. 269:973-977. [Alzforum Recommended Paper][Alzforum Milestone Paper]  

[Book Chapter] Tanzi, R.E., Kim, T.W., Kovacs, D.M., Guenette, S.Y., et al. The genes responsible for familial Alzheimer's disease: toward a common etiological pathway. In: Alzheimer's Disease: biology, diagnosis and therapeutics. J. Iqbal, Winblad, T. Nishimura, M. Takeda, N.M. Wisniewski, John Wiley & Sons Ltd., 1997, 63-69.
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