Role of Abeta142,43 in Alzheimer's Disease

Steven Younkin, MD, PhD
Mayo ClinicJacksonville (Jacksonville, FL)
Year Awarded:
Grant Duration:
April 1, 1994 to March 31, 1996
Alzheimer's Disease
Award Amount:
Grant Reference ID:
Award Type:
Award Region:
US Southeastern

Role of Abeta142,43 in Alzheimer's Disease



Scheuner, D., Eckman, C., Jensen, M., Song, X., et al. (1996) Secreted amyloid 8 -protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the Presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Medicine. 2(8):864-870. [Alzforum Recommended Paper][Alzforum Milestone Paper]  

Gravina, S., Ho, L., Eckman, C., Long, K.E., et al. (1995) Amyloid 8 protein (A8) in Alzheimer's disease brain: Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A8 40 or AB42(43). J. Biol. Chem. 270:7013-7016.  

[PMID:nd] Cheung, T.T., Ghiso, J., Shoji, M., Cai, X.D., et al. (1994) Amyloid: Characterization by radiosequencing of the carboxyterminal derivatives produced from normal and mutant amyloid beta protein precursors. Int. J. Exp. Clin. Invest. 1:30-38.[link not available]

Suzuki, N., Cheung, T.T., Cai, X.D., Odaka, A., et al. (1994) An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta-APP 717) mutants. Science. 264:1336-1340 [Alzforum Recommended Paper][Alzforum Milestone Paper]  

Don't miss out.
Receive research updates, inspiring stories, and expert advice
Please enter your first name.
Please enter your last name.
Keep me informed about: *
Please select at least one.
You must select at least one disease category.