Control of Normal Tau Levels by Molecular Chaperones

Jason Gestwicki, PhD
University of California, San Francisco (San Francisco, CA)
Year Awarded:
2015
Grant Duration:
July 1, 2015 to June 30, 2018
Disease:
Alzheimer's Disease
Award Amount:
$250,000
Grant Reference ID:
A2015297S
Award Type:
Standard
Award Region:
US Southwestern
Jason Gestwicki, PhD

Regulation Of Tau Homeostasis By Molecular Chaperones

Summary

Alzheimer’s disease is a devastating condition that impacts patients, their families and their caregivers. Since there is little in the way of treatment and as yet no cure for this disease, a major goal of our group is to pursue new and unconventional ways of preventing it. In the current project, we are trying to understand how the body’s own proteins (termed molecular chaperones) protect us against Alzheimer’s disease. At the same time, we hope to learn why this system fails during disease, so we can use this knowledge to design drugs that activate the molecular chaperones.

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