Oxidative Damage in Alzheimer's Disease

George Perry, PhD
Case Western Reserve University (Cleveland, OH)
Year Awarded:
Grant Duration:
April 1, 1997 to September 30, 1999
Alzheimer's Disease
Award Amount:
Grant Reference ID:
Award Type:
Award Region:
US Midwestern

Oxidative Damage in Alzheimer's Disease



Sayre, L.M., Smith, M.A., and Perry, G. (2001) Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem. 8(7):721-738.  

Rottkamp, C.A., Nunomura, A., Hirai, K., Sayre, L.M., Perry G., and Smith, M.A. (2000) Will antioxidants fulfill their expectations for the treatment of Alzheimer disease? Mech Ageing Dev. 116(2-3):169-179.  

Takeda, A., Perry, G., Abraham, N.G., Dwyer, B.E., Kutty, R.K., Laitinen, J.T., Peterson, R.B., Smith, M.A. (2000) Overexpression of heme oxygenase in neuronal cells, the possible interaction with tau. J Biol Chem. 275:5395-5399.  

[Book Chapter] Smith, M.A. and Perry, G. Molecular and cellular aspects of oxidative damage in Alzheimer disease. In: Free Radicals in Brain Pathophysiology, Poli, G., Cadenas, E., Packer, L., Eds.,Marcel Dekker, Inc., New York, 2000, pp 313-321. Perry, G. and Smith, M.A. (2000) Promise and pitfalls of therapeutics to modify oxidant balance in chronic disease. IDrugs. 3:371-372.  

Perry, G., Raina, A.K., Nunomura, A., Wataya, T., Sayre, L.M., Smith, M.A. (2000) How important is oxidative damage? Lessons from Alzheimer disease. Free Radic Biol Med. 28(5):831-834.  

Raina, A.K., Perry, G., Nunomura, A., Sayre, L.M., and Smith, M.A. (2000) Histochemical and immunocytochemical approaches to the study of oxidative stress. Clin Chem Lab Med. 38(2):93-97.  

Rottkamp, C.A., Nunomura, A., Raina, A.K., Sayre, L.M., Perry, G., and Smith, M.A. (2000) Oxidative stress, antioxidants, and Alzheimer disease. Alz Dis Assoc Disord. 14 Suppl 1:S62-66.  

Nunomura, A., Perry G., Pappolla, M.A., Wade, R., Hirai, K., Chiba, S., Smith, M.A. (1999) RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci. 19:1959-1964.  

Raina, A.K., Templeton, D.J., Deak, J.C., Perry, G., Smith, M.A. (1999) Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease. Redox Report. 4:23-27.  

Raina, A.K., Takeda, A., Nunomura, A., Perry, G., Smith, M.A. (1999) Genetic evidence for oxidative stress in Alzheimer's disease. Neuroreport. 10:1355-1357.  

[PMID:nd] Smith, M.A., Hirai, K., Nunomura, A., and Perry, G. (1999) Mitochondrial abnormalitites: a primary basis for oxidative damage in Alzheimer's disease. Drug Dev Res. 46:26-33. [http://www3.interscience.wiley.com/journal/55003219/abstract][link not available] Perry, G., Hirai, K., Nunomura, A., Raina, A., Smith, M.A. (1999) Neuronal oxidative damage in Alzheimer disease may be brought about by a fundamental shift in redox balance and oxidative metabolism. Recent Res Devel Neurochem. 2:277-285.  

[Book Chapter] Smith, M.A., Sayre, L.M., Perry, G. Primary involvement of oxidative damage and redox imbalance in Alzheimer and other nerodegenerative diseases. In: Redox Regulation of Cell Signaling and Its Clinical Application, Packer, L., Yodoi, J., Eds, Marel Dekker, Inc., New York, 1999, pp 115-126. Sayre, L.M., Perry, G., and Smith, M.A. (1999) Redox metals and neurodegenerative disease. Curr Opin Chem Biol. 3:220-225.  

Gerst, J.L., Siedlak, S.L., Nunomura, A., Castellani, R., Perry, G., and Smith, M.A. (1999) Role of oxidative stress in frontotemporal dementia. Dement Geriatr Cogn Discord. 10(Suppl 1): 85-87.  

[Book Chapter] Sayre, L.M., Perry, G., Smith, M.A., In situ methods for detection and localization of oxidative stress: application in neurodegenerative disorders. In: Methods of Enzymology, Vol. 309, Wetzel R, Ed. Academic Press, San Diego, 1999, pp 133-152. Castellani, R.J., Smith, M.A., Nunomura, A., Harris, P.L.R., Perry, G. (1999) Is increased redox-active iron in Alzheimer disease a failure of the copper-binding protein ceruloplasmin? Free Radic Biol Med. 26:1508-1512.  

Perry, G., Roder H., Nunomura, A., Takeda, A., Friedlich, A.L., Zhu, X., Raina, A.K., Holbrook, N., Siedlak, S.L., Harris, P.L.R., Smith, M.A. (1999) Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer's disease links oxidative stress to abnormal phosphorylation. Neuroreport 10:2411-2415.  

Perry, G., Castellani, R.J., Hirai, K., Smith, M.A. (1998) Reactive oxygen species mediate cellular damage in Alzheimer disease. J Alzheimer's Disease 1:45-55.  

Perry, G. and Smith, M.A. (1998) Is oxidative damage central to the pathogenesis of Alzheimer's disease? Acta Neurol Belg. 98:175-179.  

Smith, M.A.and Perry G. (1998) What are the facts and artifacts of the pathogenesis and etiology of Alzheimer disease? J Chem Neuroanat. 16:35-41.  

Castellani, R.J., Perry, G., Harris, P.L.R., Cohen, M.L., Sayre, L.M., Salomon, R.G., Smith, M.A. (1998) Advanced lipid peroxidation end-products in Alexander's disease. Brain Res. 787:15-18.  

Smith, M.A., Hirai, K., Hsiao, K., Pappolla, M.A., Harris, P.L.R., Siedlak, S.L., Tabaton, M., Perry G. (1998) Amyloid-B deposition in Alzheimer transgenic mice is associated with oxidative stress. J Neurochem. 70:2212-2215.  

Smith, M.A., Sayre, L.M., Anderson, V.E., Harris, P.L.R., Beal, M.F., Kowall, N., Perry, G. (1998) Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine. J Histochem Cytochem. 46:731-735.  

Smith, M.A., Vasak, M., Knipp, M., Castellani, R.J., Perry, G. (1998) Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease. Free Radic Biol Med. 25:898-902.  

Smith, M.A., Wehr, K., Harris, P.L.R., Siedlak, S.L., Connor, J.R., Perry, G. (1998) Abnormal localization of iron regulatory protein in Alzheimer's disease. Brain Res. 788:232-236.  

Perry, G., Smith, M.A., McCan, C.E., Siedlak, S.L., Jones, P.K., Friedland, R.P. (1998) Cerebrovascular muscle atrophy is a feature of Alzheimer's disease. Bran Res. 791:63-66.  

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