Oligomers role in seeding and nucleating amyloid fibrils

Rakez Kayed, PhD
University of Texas Medical Branch (Galveston, TX)
Year Awarded:
2005
Grant Duration:
April 1, 2005 to January 31, 2009
Disease:
Alzheimer's Disease
Award Amount:
$100,000
Grant Reference ID:
A2005315
Award Type:
Standard
Award Region:
US Southern

Oligomers role in seeding and nucleating amyloid fibrils

Details


Aβ is one of many peptides and proteins associated with AD. Yet, while the peptides and proteins associated with these diseases are unique in sequence, recent evidence suggests that they share common pathways for aggregation, common structural features at each stage of aggregation, and perhaps common mechanisms of toxicity. The aggregation pathway contains intermediate conformations referred to as soluble spherical oligomers. Dr. Kayed will test hypotheses regarding the role of soluble oligomers in fibril formation. The long term goal of this project is to better understand the mechanisms of the process of amyloid fibril formation in order to effectively interrupt and/or hinder amyloid formation in AD and perhaps other degenerative diseases.

Publications

Manuscripts in preparation; Diana L. Castillo-carranza, Cristian A. Lasagna-reeves, Charles G. Glabe, Erene W. Mina,George R. Jackson and Rakez Kayed; 'The role of oligomers and protofibrils in seeding and nucleating amyloid fibrillogenesis in vitro. [PMID:nd][link not available]

Rakez Kayed, Diana L. Castillo-carranza, Cristian A. Lasagna-reeves, and George R. Jackson; 'Amyloid oligomers induce tau oligomerization and fibrillization via cross-seeding in vitro'. [PMID:nd][link not available]

Audra L. Clos, Cristian A. Lasagna-Reeves, Richard Wagner, Brent Kelly, George R. Jackson and Rakez Kayed; 'Therapeutic removal of amyloid deposits in cutaneous amyloidosis induced by seeding by localized intralesional injections of anti-amyloid antibodies'. [PMID:nd][link not available]
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