CNS Delivery of Immunotherapy Using MSCs

David Cribbs, PhD
Regents of the Univ. of California (Irvine, CA)
Year Awarded:
2006
Grant Duration:
April 1, 2006 to March 31, 2008
Disease:
Alzheimer's Disease
Award Amount:
$300,000
Grant Reference ID:
A2006027
Award Type:
Standard
Award Region:
US Southwestern
This project was funded by the Revocable Trust of Margery de Scheweinitz, deceased. ADR 2006

CNS Delivery of Immunotherapy Using MSCs

Details

The focus of this proposal is on immunotherapy (vaccine) as an experimental approach to treat Alzheimer's disease. Dr. Cribbs plans to directly delivery specific antibodies to the central nervous system to attack the toxic amyloid peptide that accumulates in the brain. The antibodies will be delivered by the patient's own stem cells which will be isolated from their bone marrow. These stem cells will be genetically modified to make the antibodies, and then they will be injected into the brain where they will go to the sites of brain inflammation and secrete the therapeutic antibodies.
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