Project Details
Previous studies have found that the Alzheimer's disease beta‐amyloid protein negatively influences brain cells (neurons) and results in a communication breakdown by causing a loss of “plasticity” at the synapses (the place where neurons meet), leading to learning and memory loss. In a previous study, Dr. Nashaat Gerges and colleagues have shown that increasing neurogranin enhances the ability of the synapses to communicate. In this project, they will explore the possibility that neurogranin may reverse the negative effect of beta amyloid on synaptic plasticity. They will use a special technique that grows neurons in a dish, giving easy access for treatments and analysis of results. If successful, this could lead to future therapies for individuals with Alzheimer's disease.