What Is Macular Degeneration?

Macular degeneration is an irreversible destruction of the central area of the retina, called the macula, which provides the sharply focused central vision needed to read, recognize people and objects, and perform skilled tasks. Damage to the macula results in blind spots and blurred or distorted vision. The disease is most common in people over age 60, which is why it is often called age-related macular degeneration. Learn about the signs and symptoms of macular degeneration, treatments, prevention techniques, and ways to care for yourself or a loved one.

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Understanding Macular Degeneration

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Dry or Wet?

People can develop one or both types of the disease.

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Which Eye Will Be Affected?

The disease can affect one or both eyes.

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Early Symptoms

The early signs of macular degeneration are often subtle, and individuals may not notice symptoms until vision begins to fade.

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Who’s Affected?

The number one risk factor for macular degeneration is age. One-third of adults over age 75 are affected by age-related macular degeneration.

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Types

Types of Macular Degeneration

There are two types of macular degeneration: dry and wet. Both affect the retina, the paper-thin tissue lining the back of the eye. A person can have one or both forms.

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Dry Macular Degeneration

All macular degeneration starts as the dry form. Yellow waste deposits called drusen build up under the retina, and cells of the macula may slowly break down as a result. This is the most common type of macular degeneration.

  • Dry AMD occurs in three stages: early, intermediate, and advanced. There may be no symptoms in the early stages, but as the disease progresses, a blurry spot may appear in the center of vision that can grow larger and darker, resulting in a complete loss of central vision.
  • In its most advanced form, geographic atrophy, dry AMD can cause profound central vision loss, severely affecting a person’s quality of life.
  • Dry AMD can change suddenly into the wet, more advanced form.
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Wet Macular Degeneration

Wet macular degeneration occurs when abnormal blood vessels grow behind the macula. They can leak blood and fluid, damaging the macula and leading to distorted vision.

  • Wet AMD is usually preceded by the dry form.
  • In wet AMD, straight lines may appear wavy, and central vision loss can occur rapidly–sometimes within days.
  • Always considered the advanced stage of the disease, wet AMD accounts for approximately 10% of all cases of age-related macular degeneration. However, it results in 90% of cases of AMD-related blindness.
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Stages

How Does Macular Degeneration Affect Vision?

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Early Dry Macular Degeneration

In early dry macular degeneration, cells in the macula begin to sicken, and parts of the central vision become blurry. This may be difficult to notice at first, especially if the other eye is healthy, which can often hide the problems of the sick eye. Some people may find they need more light to read, but otherwise, they may not notice problems with their vision.

Intermediate Dry Macular Degeneration

As dry macular degeneration slowly progresses, the blurring worsens, and the blurred area increases in size. Blind spots (called scotomas) may develop. The person may begin to have trouble telling the difference between similar colors, or shades of the same color.

Late Dry Macular Degeneration

In the very late stage of dry macular degeneration, or geographic atrophy, macula cells begin to die, and large portions of the center of vision may become blurred. People at this stage may have blind spots and areas that appear wavy or distorted. Not all dry macular degeneration will progress to wet macular degeneration, but when it does, it often progresses much more quickly than the dry form.

Wet Macular Degeneration

For some people with dry macular degeneration, new blood vessels grow under the retina, forming “wet” macular degeneration. In the early stages, these vessels may cause the retina to bulge or pucker. This results in distortion or “twisting” of vision. Think of how curved mirrors change the images they reflect. A bent or puckered macula also changes the way light hits the retina. When this happens, things that should appear straight start to bend or appear wavy.

Late Wet Macular Degeneration

In late wet macular degeneration, blood vessels push through the macula, causing some to break, and leave scar tissue. The areas around the leak may break down resulting in severe blind spots and even more waviness or distortion. Wet macular degeneration worsens much more quickly than dry macular degeneration.

The same family on the beach at sunset, with all faces clearly visible except for the man in the middle, whose face is still partially blurred. The rest of the family is smiling at the camera.
The family stands together on the beach at sunset, with all faces visible except for the man in the middle, whose face is partially blurred.
The same family on the beach with the same people visible. The blur obscures more of the faces of the older woman, the man in the middle, and the younger woman with curly hair.
The same family on the beach at sunset, with the same people visible. In this image, the faces of the older woman and the man in the middle are blurred.
A group photo of a family standing on a beach at sunset. The family consists of a man in a sweater, a young boy in an orange vest, an older woman, a younger woman with curly hair, and a woman with long braids. The faces of the older woman and the younger woman with curly hair are blurred.
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Risk Factors

Who is at Risk of Developing Macular Degeneration?

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Medical experts are not sure exactly what causes age-related macular degeneration (AMD), but some factors may increase your risk of developing it.

Here are some general risk factors to keep in mind, including:

  • Age
  • Smoking
  • Family History
  • Gender
  • Race
  • Prolonged Sun Exposure
  • Diet
  • Obesity
  • High Blood Pressure
  • Eye Color
  • Inactivity

Browse other potential risk factors and how to lower your risk.

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By the Numbers

Facts & Figures

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Did you know?

Macular degeneration is a leading cause of vision loss in Americans aged 60 and older.

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20 Million

As many as 20 million U.S. adults aged 40 and older are living with some form of age-related macular degeneration.

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A Leading Cause of Blindness

Advanced age-related macular degeneration is a leading cause of irreversible blindness and visual impairment in the world.

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Program Impact

Accelerating Groundbreaking Research

Macular Degeneration Research, a BrightFocus Foundation program, is working to find the root causes of this debilitating disease and pioneer prevention strategies and treatments to end it for good.

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Macular Degeneration Research-funded scientist Juliette Wohlschlegel, PhD.

With our funding, scientists around the world are developing, testing, and investigating hundreds of ideas to prevent, treat, and cure macular degeneration.

We’ve invested nearly $53 million in macular degeneration research to date across 348 research grants.

Resources

Recent Resources & Information

Browse expert-vetted articles and resources to better understand, manage, and prevent macular degeneration.
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Macular Chats

Supporting the Supporters: Care Partners in Vision Loss

In recognition of National Caregivers Month, this episode explores the vital role of those who support individuals living with vision loss—whether family members, professionals, or volunteers.

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Macular Chats

Understanding Stem Cell Research for Macular Degeneration

Dr. Jeffrey Stern and Dr. Sally Temple, Principal Investigators and Co-Founders of the Neural Stem Cell Institute, will explain what stem cells are and share the latest updates from clinical trials.

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Story

Finding Purpose and Community Through Supporting Research

Dave and Leanna Palmer share their commitment to supporting Macular Degeneration Research.

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Expert Information

How Retinal and Brain Implants Restore Partial Sight

Artificial vision systems utilizing these technologies show promise for individuals with profound vision loss in early trials.

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Macular Chats

Saving Sight: How Long-Term Treatment Helps Slow Geographic Atrophy

Join Dr. Sara Fard, a retina specialist at Illinois Retina Associates, as she explains the benefits of sustained GA treatment, including slowing the rate of vision loss, protecting retinal tissue, and supporting daily visual function.

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Macular Chats

Innovative Science Driving Macular Degeneration Progress

Dr. Diane Bovenkamp highlights several of this year’s groundbreaking projects and explain how they’re driving progress in early detection, risk reduction, new treatments—and ultimately, a cure.

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Macular Chats

Vitamins and Supplements for Retinal Health

Dr. Brian McKay and Dr. Murray Brilliant discuss the widely used AREDS2 nutrient formula and exciting new research into L-DOPA, a naturally occurring compound that may offer a stronger role in maintaining retinal health.

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Expert Information

Emerging Treatments Offer New Hope for Dry and Wet Age-Related Macular Degeneration

Promising new treatments in late-stage clinical trials could transform how we treat age-related macular degeneration.

Current treatments for wet age-related macular degeneration (AMD) require eye injections approximately every 4 – 8 weeks. Learn about a potential new treatment that may require less frequent injections.
Downloadable Resource

Treatments for Macular Degeneration

Find information on treatment options for dry and wet age-related macular degeneration.

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