Myoungsup
Sim

Myoungsup Sim, PhD, is a research scientist at the Duke Eye Center in the laboratory of Dr. Paloma B. Liton. His research focuses on the cellular and molecular mechanisms that regulate intraocular pressure in glaucoma, with particular emphasis on the conventional outflow pathway. His work has defined the role of primary cilia across trabecular meshwork and Schlemm’s canal cells as mechanosensors that contribute to the regulation of aqueous humor outflow. Building on these findings, Dr. Sim introduced genetically encoded nitric oxide biosensors (GeNOp) into Schlemm’s canal to enable in vivo visualization of nitric oxide dynamics, demonstrating its role as a key regulator in the outflow pathway. Together, these studies support a primary cilia–nitric oxide axis contributing to intraocular pressure homeostasis. His current research investigates therapeutic strategies that enhance endogenous nitric oxide signaling by restoring ciliary function. Through this work, he aims to develop mechanism-based approaches for improving outflow function and achieving more effective and sustained control of intraocular pressure in glaucoma.