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Grants > Potential Therapy of Age-Related Macular Degeneration With Small Molecules Updated On: Feb. 3, 2025
Macular Degeneration Research Grant

Potential Therapy of Age-Related Macular Degeneration With Small Molecules

Principal Investigator

Dwight Stambolian, MD, PhD

University of Pennsylvania

Philadelphia, PA, USA

About the Research Project

Program

Macular Degeneration Research

Award Type

Standard

Award Amount

$100,000

Active Dates

April 01, 2008 - June 30, 2010

Grant ID

M2008065

Goals

This project is looking for a small molecule that can penetrate the eye and diminish the eye inflammation that occurs in AMD. If successful, this small molecule can be administered at the earlier stages of AMD to halt progression to the later stages and eventual blindness. To identify such a molecule, we will screen a small molecule library and confirm its efficacy in a test tube before moving onto animal models.

Summary

Current treatments for AMD do not restore vision. In wet AMD, treatment is directed at the terminal stages, making it impossible to return vision to 20/20. For the dry type, the only treatment is a special vitamin preparation that is only effective in slowing the progression of AMD in some people. The researchers are investigating a small molecule that can penetrate the eye and diminish the eye inflammation that occurs in AMD. If successful, this small molecule could be administered in the earlier stages of AMD to halt disease progression and prevent blindness. They will identify such a molecule by screening a small molecule library and then will confirm its efficacy in a test tube before moving on to animal models.