Ophthalmic Examination of Dizygotic Twins in Queensland
Principal Investigator
David Mackey, MD
Royal Victorian Ear and Eye Hospital
East Melbourne, Australia
About the Research Project
Program
Award Type
Standard
Award Amount
$80,000
Active Dates
April 01, 2005 - March 31, 2007
Grant ID
G2005002
Summary
Glaucoma is thought to have a major genetic component. Several genes have been identified, but so far these only accounts for 5% of glaucoma cases. Twin studies are an important tool for determining the relative contribution of genes or environment in any measure. If there is very little genetic component, then identical twins will vary as much as non identical twins. Dr. Mackey will analyze pressure, refraction, optic nerve, corneal thickness and many other measures in his study, and then compare all the numerical measurements of the twins with their DNA markers to discover where similar twins consistently have similar DNA markers. Discovering the genes that cause glaucoma will enable other family members to be tested and predict who is at high risk or low risk of developing glaucoma. This will allow better early screening for glaucoma and potentially lead to the development of new treatments.
Grants
Related Grants
National Glaucoma Research
Understanding How Variants in LOXL1 Affect Pseudoexfoliation Glaucoma Risk
Active Dates
July 01, 2024 - June 30, 2026
Principal Investigator
Hannah Youngblood, PhD
Understanding How Variants in LOXL1 Affect Pseudoexfoliation Glaucoma Risk
Active Dates
July 01, 2024 - June 30, 2026

Principal Investigator
Hannah Youngblood, PhD
National Glaucoma Research
Retinal Ganglion Cell Axon Degeneration in a 3D Microfluidic Hydrogel Model
Active Dates
July 01, 2024 - June 30, 2026
Principal Investigator
Shruti Patil, PhD
Retinal Ganglion Cell Axon Degeneration in a 3D Microfluidic Hydrogel Model
Active Dates
July 01, 2024 - June 30, 2026

Principal Investigator
Shruti Patil, PhD
National Glaucoma Research
The Role of Microtubules in Glaucomatous Schlemm’s Canal Mechanobiology
Active Dates
July 01, 2024 - June 30, 2026
Principal Investigator
Haiyan Li, PhD
The Role of Microtubules in Glaucomatous Schlemm’s Canal Mechanobiology
Active Dates
July 01, 2024 - June 30, 2026

Principal Investigator
Haiyan Li, PhD