Investigating the role of impaired mitochondrial dynamics in Exfoliation Glaucoma
Principal Investigator
Arunkumar Venkatesan
SUNY Upstate Medical University
Syracuse, NY, United States
About the Research Project
Program
Award Type
Other
Award Amount
$30,000
Active Dates
July 24, 2023 - June 23, 2024
Grant ID
CG2023001
Summary
Exfoliation glaucoma (XFG) is a more severe form of open angle glaucoma and a blinding disease. The eye starts accumulating white flaky fibrillar aggregates blocking fluid exit from the eye. As XFG is a multifactorial disease, evidence suggests that the pathogenesis of the disease is associated with genetic variants, environmental factors, protein aggregation, oxidative stress, and cellular dysfunction. This proposal aims to study defects in mitochondrial function in XFG patient-derived primary cells and the relationship of mitochondrial dysfunction to cellular senescence (aging cells). Mitochondria are essential cellular organelles that play critical roles in cellular energy metabolism and are known to be responsible for oxidative stress-induced damage in age-dependent neurodegenerations such as glaucoma. Hence, maintaining mitochondrial health is evolving as a fundamental part of preventing aging diseases. This study will evaluate how mitochondrial function is impaired in XFG and examine therapeutic strategies to enhance mitochondrial function for the treatment of XFG.
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