Pressure-Induced Axon Damage and Its Link to Glaucoma-Related Vision Loss

This study will use the in vivo data from meticulously controlled experimental glaucoma (EG) models. By combining digital volume correlation and a novel axon-centric method, we will measure ONH deformations, estimate 3D axonal paths, and investigate the acute IOP-induced mechanical insult on axon level before axonal injury. These results will be compared with the neural tissue loss during EG development in the same nonhuman primates (NHP) eye. This project will establish a fundamental connection between biomechanics and glaucomatous optic neuropathy.

Upon completion, this study will identify the specific type of mechanical insult to axons that best predicts neural tissue loss. This insight will allow the community to focus efforts on minimizing this specific insult.