Impact of Declined Immunity on Age-Related Inflammation and Dementia
Principal Investigator
Alon Monsonego, PhD
Ben-Gurion University of the Negev (BGU)
Beer-Sheva, Israel
About the Research Project
Program
Award Type
Standard
Award Amount
$466,417.59
Active Dates
January 01, 2024 - December 31, 2026
Grant ID
CA2023002
Co-Principal Investigator(s)
Daniel M. Altmann, PhD, Ben-Gurion University of the Negev (BGU)
Goals
Revealing the role of inflammation and blood-brain barrier integrity in Alzheimer’s disease pathology.
Unique and Innovative
We will correlate clinical phenotype, MRI and PET CNS imaging, immune subset transcriptomics and systemic inflammation. We will identify highly characterized, amyloid positive (using amyloid PET) Alzheimer’s subjects and controls (amyloid negative) and conduct detailed clinical, neurological and neuropsychological evaluation.
Foreseeable Benefits
1) an established link between age-related declined immunity, BBB dysfunction and the progression of AD which identifies new targets for early intervention, 2) early diagnosis of AD trajectory in individuals exhibiting amyloid deposition in the brain and/or MCI, and 3) different trajectory patterns of individuals diagnosed with AD, which then allows personalized treatment and better treatment efficacy.