Aqueous Humor Oxidative Stress Markers in Glaucoma

Our proposed study will examine the aqueous humor, the fluid in the front of the eye, of patients who are undergoing eye surgery. We will measure both a byproduct (hydrogen peroxide) and a protectant (ascorbic acid) of oxidative damage, as well as oxygen levels in different parts of the front of the eye. By aiding in further understanding of this oxidative mechanism of glaucoma damage, it may lead to innovative therapies for this devastating condition.

Glaucoma, the second leading cause of blindness worldwide, is characterized by damage to the optic nerve which transmits visual information from the eye to the brain. Most cases are associated with increased eye pressure and decreased outflow through the drainage meshwork in the front of the eye. Current theories suggest that this age-related disease, as well as other eye conditions like cataract and macular degeneration, may be related to oxidative damage, toxic effects of excess oxygen forming harmful molecules called free radicals.