Genetic and environmental risks for age-related macular degeneration

Luba Robman, MBBS, PhD
Centre for Eye Research Australia, The University of Melbourne (Melbourne, Australia)
Year Awarded:
2008
Grant Duration:
April 1, 2008 to March 31, 2010
Disease:
Macular Degeneration
Award Amount:
$100,000
Grant Reference ID:
M2008082
Award Type:
Standard
Award Region:
International

Genetic risks for AMD in Australians of Northern and Southern European origin

Summary

This study will investigate whether the risk of AMD, which is pre-determined by genes, can be modified by changes in diet. The study will genotype AMD cases and controls from a large Australian cohort of participants of Anglo-Celtic and Mediterranean origin to define genetic risk for AMD.

Details

This study will investigate whether the risk of AMD, which is pre-determined by genes, can be modified by changes in diet. The study will genotype AMD cases and controls from a large Australian cohort of participants of Anglo-Celtic and Mediterranean origin to define genetic risk for AMD. They will identify the AMD genes in elderly from this cohort (about 8,000 people), and correlate genetic status of the participants with their dietary history and condition of the retina. This might be a first step towards personalized medical care, based upon knowledge of susceptibility to a disease using genetic and other risk factor information.

Publications

Adams MK, Simpson JA, Aung KZ, Makeyeva GA, Giles GG, English DR, Hopper J, Guymer RH, Baird PN, Robman LD. Am J Epidemiol. Abdominal Obesity and Age-related Macular Degeneration. 2011 Mar 21. PubMed Icon Google Scholar Icon

Adams MK, Simpson JA, Richardson AJ, Guymer RH, Williamson E, Cantsilieris S, English DR, Aung KZ, Makeyeva GA, Giles GG, Hopper J, Robman LD, Baird PN. Hum Mol Genet. 2012 Sep 17. PubMed Icon Google Scholar Icon