Exploring a novel abnormal regulatory pathway in Alzheimer's disease brain cell connections

Catherine Clelland, PhD
Columbia University (New York, NY)
Year Awarded:
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April 1, 2010 to September 30, 2012
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US Northeastern

The Role of miR-138 in Alzheimer's Disease Dendritic Spine Pathology


We will test if dysregulation of the miR-138 controlled pathway contributes to dendritic spine pathology in a murine tauopathy model. We believe this project is highly innovative because if successful, this study will be one of the first to directly link the dysregulation of a miRNA regulated pathway to the in vivo dendritic spine pathology seen in a mouse model of human tauopathy.


We are going to investigate the role of an important class of regulatory proteins in Alzheimer's disease. The success of this project may be beneficial to the public in the form of new treatment developments.