Research in Briefs

Research in Brief

Extracellular vesicles isolated from the blood of people with Down syndrome-related Alzheimer’s disease have been shown to seed toxic tau species in the brains of normal mice, shedding light on the uptake and transmission of toxic tau.

Jan 20, 2022
Macular Degeneration Research

As retinal cells transition from one state to another, they exhibit molecular changes that correspond to those of liver cells.

Jan 13, 2022
Alzheimer's Disease Research

Tau tangles tend to accumulate in brain cells that also express the Wolframin-1 protein—a discovery that’s been corroborated in human tissue and a mouse model.

Jan 6, 2022
National Glaucoma Research

BrightFocus-funded researchers crosslink exfoliation syndrome (XFS), a condition that can lead to glaucoma, with common comorbidities and shared risk factors as a way of predicting which patients are at increased risk.

Dec 22, 2021
Research in Brief

Learn about a potential blood test to diagnose AD and monitor its progression and response to treatments.

Dec 21, 2021
Research in Brief

People with Alzheimer’s pathology, but no significant cognitive decline (termed, resilient), have increases in synaptic signaling and energy production and decreased damage to waste clearance and anti-oxidant proteins when compared to people with AD-dementia.

Dec 17, 2021
National Glaucoma Research

After early human development, the nerve cells of the eye no longer regenerate. Researchers are looking for ways to genetically manipulate this pathway to protect and repair damaged retinal ganglion cells in glaucoma.

Dec 16, 2021
Research in Brief

Recent work from BrightFocus grantee Zhuohao He, PhD, advances knowledge of tau in Alzheimer’s disease and other neurodegeneration, and opens new avenues for drug development.

Dec 13, 2021
Alzheimer's Disease Research

Neurodegeneration in a key brain region has been associated with sleep disturbances in people at risk for Alzheimer’s disease – a finding which could lead to earlier intervention and better treatment options.

Dec 10, 2021
Research in Brief

High-throughput analysis reveals that retinal genes are influenced by a high-fat diet alone, independent of gut bacteria, in ways that increase susceptibility to macular degeneration.

Dec 1, 2021