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Different tasks and movements activate different parts of the brain. Scientists are working to refine imaging that can detect early Alzheimer’s.

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BrightFocus Funds Research Aimed at Early Detection of Alzheimer’s

A BrightFocus grantee is adapting MRI and other imaging tests to create a multimodal approach to diagnosing early Alzheimer’s. Earlier diagnosis could mean earlier treatment and cure.

April 9, 2018

It may take up to 15 years and more than $1 billion to bring a new medication to market

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Success at Last! Two New Glaucoma Drugs Reach the Market

Two new pressure-lowering glaucoma medications have been approved by the FDA and are becoming available in the United States. Each is unique, and one is the first in a new class of drugs.

March 29, 2018

Beta-amyloid plaques, inflammation, and tau tangles are major culprits behind late-onset AD, but they show up at different times over its long course. Future drug trials will target the right stage of disease in the right patient, says this expert.

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Future Treatments for Alzheimer’s Disease: Where Are They Headed?

An expert reveals what recent clinical trials have taught us, and why a one-size-fits-all approach won’t work.

February 16, 2018

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BrightFocus Foundation Joins US Army-Affiliated Effort on Regenerative Medicine

BrightFocus Foundation has joined a new partnership to support innovative science to regenerate damaged visual pathways in glaucoma.

February 6, 2018

Sheldon Rowan in the lab he shares with Allen Taylor and other colleagues at the Tufts-USDA Human Nutrition Research Center on Aging. Their lab is devoted to studying how nutrition affects age-related vision diseases, including AMD.

Science News

Diet, Gut Bacteria, and AMD – New Research Shows the Connection

At Tufts University in Boston, BrightFocus grantees Sheldon Rowan and Allen Taylor are testing whether diet protects against AMD by influencing the microbiome, or bacteria living in our body. They are leaders in the field of nutrition and the aging eye.

December 28, 2017

Science News

Cell Models Reveal a Shared Early Pathway to Macular Disorders

Ruchira Singh and colleagues at the University of Rochester and worldwide have shown that even rare forms of macular degeneration develop in ways similar to AMD, with drusen formation and extracellular proteins. The goal ahead: effective early treatment approaches.

December 27, 2017

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Understanding Tau’s Role in Origin and Spread of Alzheimer’s Disease

Using atomic-level imaging, Paul Seidler, UCLA, looks at how tau protein creates tangles in Alzheimer’s—and how to stop it with well-designed drugs. The work is supported by a partnership between BrightFocus and Alzheimer’s Los Angeles. .

December 13, 2017

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Diet and Macular Degeneration: Some Good News on Delaying the Onset of Disease

Funded in part by BrightFocus’ Macular Degeneration Research program, Allen Taylor, MD, and his colleagues at Tufts University are studying how dietary patterns can affect the eyes and one’s risk of macular degeneration.

December 11, 2017

The top images show the pouch-like openings that caveolins form in the outflow pathway of human eye. In the lower panel: electron micrograph showing numerous caveolae in Schlemm’s canal of mouse.

Science News

Do Pressure Sensors Fail in Glaucoma? A BrightFocus-funded Hypothesis

BrightFocus-funded researcher, Michael Elliott, PhD, of the University of Oklahoma Health Sciences Center, continues to make rich discoveries about pressure-sensing cells in glaucoma.

December 7, 2017