A group of researchers based at the University of California, San Francisco (UCSF), have shown that when cardiovascular risk factors (CVRF) such as elevated glucose and high blood pressure begin in early adulthood, they are associated with significantly worse cognitive function in middle age compared with having no CVRF.
In an online report published April 2, 2014, BrightFocus researchers Matthew Campbell, PhD, Sarah Doyle, PhD, and Peter Humphries, PhD, and their teams, have reported from studies in mice that the inflammatory cytokine interleukin-18 (IL-18) can prevent choroidal neovascularization (CNV) formation—the fragile, leaky blood vessels forming on the retina that are the hallmark of wet AMD—and is not toxic to the retinal pigment epithelium.
Now some researchers are hopeful that nanotechnology will eventually make it possible to deliver anti-vascular endothelial growth factor treatments to the back of the eye in drops, rather than injections, to stop blood vessel growth.
Experts have long recognized that the number of deaths from Alzheimer’s disease (AD) tends to be underreported. Now a new study published in Neurology attempts to quantify that under-reporting and projects the AD mortality rate to be five to six times higher than official estimates, suggesting that AD may be responsible for more than 500,000 annual deaths in the United States.
BrightFocus-funded Dr. Maya Koronyo-Hamaoui is the senior author on a groundbreaking publication that reported the ACE protein, which can increase blood pressure to dangerous levels in the body’s blood stream, can actually help to clear beta-amyloid in the brain by stimulating the immune system.
No treatments have yet been found to halt or reverse the progress of Alzheimer's disease. Now, a protein discovered 25 years ago in the research lab of Paul Lombroso, MD, the Elizabeth Mears and House Jameson Professor in the Child Study Center at Yale, may offer new hope.
February 7, 2014
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