A Genetic Model for “Wet” Age-Related Macular Degeneration

Neena Haider, PhD
The Schepens Eye Research Institute (Boston, MA)

Co-Principal Investigators

Kip Connor, PhD
Massachusetts Eye and Ear Infirmary
Year Awarded:
Grant Duration:
July 1, 2014 to June 30, 2016
Macular Degeneration
Award Amount:
Grant Reference ID:
Award Type:
Award Region:
US Northeastern
Neena Haider, PhD

Novel Genetic Model of Choroidal Neovascular Age-Related Macular Degeneration


Age-related macular degeneration (AMD) is easily becoming the number one cause of blindness in the world today. A major problem in finding a cure is not knowing what causes the disease and not having a good model system to use for testing a therapy. In this study, we utilize a novel genetic model that recapitulates the blood vessel defect known as choroidal neovascularization, which refers to the new growth of fragile, leaky blood vessels seen in “wet” AMD patients. If successful, this will give us a powerful tool to identify factors that can cause this disease outcome, help us understand the disease process, and serve as a model to test therapies.

About the Researcher

Dr. Haider has been involved in the field of genetics and retinal disease for over 15 years. She received her Ph.D. in Genetics from University of Iowa and did a postdoctoral fellowship at The Jackson Laboratory. She has published more than 30 original papers in such journals as Nature Genetics, Human Molecular Genetics, and PloS One, focusing on human genetics, mouse model systems, and genomics in regulation and modulation of human retinal disease.


Hasegawa E, Sweigard H, Husain D, Olivares AM, Chang B, Smith KE, Birsner AE, D'Amato RJ, Michaud NA, Han Y, Vavvas DG, Miller JW, Haider NB, Connor KM. Characterization of a spontaneous retinal neovascular mouse model. PLoS One. 2014 Sep 4;9(9):e106507. doi: 10.1371/journal.pone.0106507. eCollection 2014. PubMed PubMed Icon Google Scholar Icon

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