Novel ConeSpecific GenesTherapeutic Targets for MD

Breandan Kennedy, PhD
University College Dublin (Dublin 4, Ireland)
Year Awarded:
2005
Grant Duration:
April 1, 2005 to March 31, 2007
Disease:
Macular Degeneration
Award Amount:
$98,625
Grant Reference ID:
M2005015
Award Type:
Standard
Award Region:
International

Novel ConeSpecific GenesTherapeutic Targets for MD

Summary

 

Details

Vision is possible because of the abundance of specialized structures known as cone photoreceptor cells, located in the macula. Macular degeneration causes these cones to die and results in severe visual handicap and blindness in affected individuals. If a means to help cone photoreceptors live longer can be identified, this will significantly improve the quality of life of affected patients. It is likely that factors involved in the initial formation of cones during development, and products that are specifically found in cone photoreceptors, will in turn promote cone survival. Once these factors have been identified, the long-term goal will be to determine if the addition of these factors is therapeutically beneficial to humans affected by macular degeneration by slowing or preventing the onset of blindness.

Publications

Kennedy BN, Alvarez Y, Brockerhoff SE, Stearns GW, Sapetto-Rebow B, Taylor MR, Hurley JB. Identification of a zebrafish cone photoreceptor-specific promoter and genetic rescue of achromatopsia in the nof mutant. Invest Ophthalmol Vis Sci. 2007 Feb;48(2):522-9. PubMed  

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