The importance of macrophage senescence in regulating angiogenesis in macular degeneration
Public Health Relevance: Age-related macular degeneration is the leading cause of blindness in people over 50 years of age. Mechanisms that lead to immune dysfunction as identified in this proposal that are relevant to the pathophysiology of abnormal angiogenesis will help us devise immune based therapies that ameliorate disease progression and ultimately blindness.
Although epidemiologic studies suggest that statins that lower cholesterol reduce the risk of progression in AMD, our study is unique in that it directly evaluates the role of cholesterol within drusen during the progression of AMD.
First published on: April 1, 2010
Last modified on: April 4, 2012