Etiology and Pathogenesis of Age-related Macular Degeneration

Zhenglin Yang, MD
University of California, San Diego (La Jolla, CA)
Year Awarded:
2008
Grant Duration:
April 1, 2008 to March 31, 2010
Disease:
Macular Degeneration
Award Amount:
$100,000
Grant Reference ID:
M2008092
Award Type:
Standard
Award Region:
US Southwestern

Functional Study of HTRA1 and Age-related Macular Degeneration

Summary

Identification and functional studies of the HTRA1, a gene that has substantial impact on the risk of AMD, may define key molecular pathways involved in its pathogenesis. The experiments will yield novel mechanistic insights relevant to the pathogenesis of both early and late AMD. This may lead to therapies directed at the underlying cause and pre-symptomatic diagnosis leading to earlier intervention.

Details


Identification and functional studies of the HTRA1, a gene that has substantial impact on the risk of AMD, may define key molecular pathways involved in its pathogenesis. The experiments will yield novel mechanistic insights relevant to the pathogenesis of both early and late AMD. This may lead to therapies directed at the underlying cause and pre-symptomatic diagnosis leading to earlier intervention.

Publications

Yang Z, Chen Y, Lillo C, Chien J, Yu Z, Michaelides M, Klein M, Howes KA, Li Y, Kaminoh Y, Chen H, Zhao C, Chen Y, Al-Sheikh YT, Karan G, Corbeil D, Escher P, Kamaya S, Li C, Johnson S, Frederick JM, Zhao Y, Wang C, Cameron DJ, Huttner WB, Schorderet DF, Munier FL, Moore AT, Birch DG, Baehr W, Hunt DM, Williams DS, Zhang K. (2008) Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J Clin Invest. 2008 Aug;118(8):2908-16.  

Yang Z, Stratton C, Francis PJ, Kleinman ME, Tan PL, Gibbs D, Tong Z, Chen H, Constantine R, Yang X, Chen Y, Zeng J, Davey L, Ma X, Hau VS, Wang C, Harmon J, Buehler J, Pearson E, Patel S, Kaminoh Y, Watkins S, Luo L, Zabriskie NA, Bernstein PS, Cho W, Schwager A, Hinton DR, Klein ML, Hamon SC, Simmons E, Yu B, Campochiaro B, Sunness JS, Campochiaro P, Jorde L, Parmigiani G, Zack DJ, Katsanis N, Ambati J, Zhang K. Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med. 2008 Oct 2;359(14):1456-63. Epub 2008 Aug 27.  

Yang Z, Tong Z, Chen Y, Zeng J, Lu F, Sun X, Zhao C, Wang K, Davey L, Chen H, London N, Muramatsu D, Salasar F, Carmona R, Kasuga D, Wang X, Bedell M, Dixie M, Zhao P, Yang R, Gibbs D, Liu X, Li Y, Li C, Li Y, Campochiaro B, Constantine R, Zack DJ, Campochiaro P, Fu Y, Li DY, Katsanis N, Zhang K. Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet. 2010 Feb 5;6(2):e1000836.  

Don't miss out.
Receive research updates, inspiring stories, and expert advice
Please enter your first name.
Please enter your last name.
Keep me informed about: *
Please select at least one.
You must select at least one disease category.