Neurotrophin Signaling in the Human Trabecular Meshwork

Robert Wordinger, PhD
University of N. Texas Health Scien (Fort Worth, TX)
Year Awarded:
Grant Duration:
April 1, 1999 to March 31, 2001
Award Amount:
Grant Reference ID:
Award Type:
Award Region:
US Southern

Neurotrophin Signaling in the Human Trabecular Meshwork


The trabecular meshwork is an intricate system of drainage canals through which the intraocular fluid, also called the aqueous humor, drains from the eye. This drainage helps the eye maintain normal fluid pressure. Dr. Wordinger has hypothesized that a certain class of growth factors, called neurotrophins, play an important role in cells of the trabecular meshwork (TM). He hopes to improve our knowledge of the normal physiology of aqueous humor outflow via the TM and to determine if neurotrophins play a role in glaucoma. If the latter proves to be true, existing compounds for regulating neurotrophins can be tested for their therapeutic value.


Liu, X., Lambert, W., Agarwal, R., Talati, M., Cross, W., Clark, A., and Wordinger, R.J. (2001) Human trabecular meshwork cells express the ciliary neurotrophic factor (CNTF) tripartitc receptor complex. Exp. Eye Res. 72:711-717.  

Wordinger, R.J., Lambert, W., Agarwal, R., Talati, M., and Clark, A.F. (2000) Human trabecular meshwork cells secrete neurotrophins and express neurotrophin receptors (Trk). Invest. Ophthalmol.Vis.Sci. 41:3833-3841.  

Wordinger, R.J. and Clark, A.F. (1999) Effects of glucocorticoids on the trabecular meshwork: towards a better understanding of glaucoma. Progress in Retinal and Eye Research. 18(5):629-667.  

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