Summary
TGF-beta and Wnt signaling pathways are involved in intraocular pressure regulation and glaucoma pathogenesis. We are trying to identify the genes that mediate the crosstalk between the two pathways. By using these genes as therapeutic targets, we will be able manipulate both pathways at the same time and find a more effective way of restoring aqueous outflow in the TM, thereby lowering IOP and treating glaucoma.