Role of sorLA in trafficking and processing of APP

M. Andersen, PhD
Max-Delbrueck Center for Molecular Medicine (Berlin, Germany)
Year Awarded:
2005
Grant Duration:
April 1, 2005 to March 31, 2007
Disease:
Alzheimer's Disease
Award Amount:
$100,000
Grant Reference ID:
A2005202
Award Type:
Standard
Award Region:
International

Role of sorLA in trafficking and processing of APP

Details


A hallmark of the brain in Alzheimer's disease is the occurrence of “plaques,” dense deposits of proteinaceous material that are toxic to nerve cells. Plaques are mainly composed of a small peptide called the amyloid-beta (Aβ), which is derived from a larger protein in nerve cells, the amyloid precursor protein (APP). Dr. Anderson has identified a novel protein in nerve cells called sorLA that seems to play an important role in the APP breakdown into Aβ. His studies suggest that sorLA prevents APP from going into specific compartments of the nerve cell where breakdown into Aβ occurs. He believes that raising sorLA levels will prevent Aβ production, and therefore significantly decrease, or even eliminate, plaque accumulation in the brain. If confirmed, Dr. Anderson's studies could be used to develop new ways to combat Alzheimer's disease through drugs designed to increase sorLA levels in the brain.

Publications

Andersen, O.M. and Willnow, T.E. (2006) Lipoprotein receptors in Alzheimer's disease. Trends Neurosci. Dec;29(12):687-94.  

Willnow, T.E. and Andersen, O.M. (2006) Pin-pointing APP processing. Mol. Interv. Jun;6(3):137-9.  

Andersen, O.M., Schmidt, V., Spoelgen, R., Gliemann, J., Behlke, J., Galatis, D., McKinstry, W.J., Parker, M.W., Masters, C.L., Hyman, B.T., Cappai, R. and Willnow, T.E. (2006) Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry. Feb 28;45(8):2618-28.  

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