Summary
The severity of Alzheimer's disease (AD) symptoms is directly linked to levels of the amyloid beta (i.e., the generation of Abeta peptide), as shown by genetic studies. Abeta levels and the amount of amyloid deposits increase in AD, yet factors that increase Abeta levels at the synapses (the connections between nerve cells) remain largely unknown. The goal of this project is to study the role of a type of synapse protein, called Neurexins, in regulating amyloid deposition in AD. Collectively, this research proposal will provide novel insights into the development and progression of Alzheimer's disease.