Identifying the Role of a Brain-specific Protein Centaurin-α1, in Alzheimer’s Disease

Ryohei Yasuda, PhD
Max Planck Florida Institute for Neuroscience (Jupiter, FL)
Year Awarded:
2015
Grant Duration:
July 1, 2015 to June 30, 2018
Disease:
Alzheimer's Disease
Award Amount:
$250,000
Grant Reference ID:
A2015251S
Award Type:
Standard
Award Region:
US Southeastern
Ryohei Yasuda, PhD

The role of Centaurin-α1 in Alzheimer’s Disease Pathology

Summary

It is thought that Alzheimer’s disease (AD) is caused by accumulation of beta amyloid (Aβ) in the brain. We recently identified that a signaling protein called centaurin-α1 (CentA1) causes Aβ -induced dysfunction of neurons and thus potentially contributes to brain dysfunction in AD. In this project, we will further study the potential roles of CentA1 in AD using newly developed CentA1 knockout mice in combination with the mouse model for Alzheimer’s disease. We hope that this will lead to new therapeutics for AD targeting CentA1.

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