Regulation of Tau Protein Phosphorylation in Brain

Hemant Paudel, PhD
Lady Davis Institute for Med. Rsrch (Montreal, Quebec, Canada)
Year Awarded:
Grant Duration:
April 1, 1998 to March 31, 2000
Alzheimer's Disease
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Regulation of Tau Protein Phosphorylation in Brain



Sobue, K., Agarwal-Mawal, A., Li, W., Sun, W., Miura, Y., and Paudel, H.K. (2000) Interaction of neuronal Cdc2-like protein kinase with microtubule-assoicated protein tau. J. Biol. Chem. 275(22):16673-16680.  

Huang, K.X., and Paudel, H.K. (2000) Ser67 phospyorylated inhibitor 1 is a poten protein phosphatase 1 inhibitor. Proc. Natl. Acad. Sci, USA. 97(11):5824-5829.  

Hashiguchi, M., Sobue, K., and Paudel, H.K. (2000) 14-3-3zeta is an affector of tau protein phosphorylation. J. Biol. Chem 275(33):25247-54.  

Paudel, H.K. and Li, W. (1999) Heparin-induced conformational change in microtubule-associated protein tau as detected by chemical cross-linking and phosphopeptide mapping. The Journal of Biological Chemistry. 274(12):8029-8038.  

Schipper, H.M., Agarwal-Mawal, A. and Paudel, H.K. (1999) The topography and subcellular distribution of mitogen-activated protein Kinase Kinase1 (MEK1) in adult rat brain and differentiating PC12 cells. Neuroscience. 93(2):585-595.  

Li, W., Ma, K.K., Sun, W., and Paudel, H.K. (1998). Phosphorylation sensitizes microtubule-associated protein tau to Al(3+)-induced aggregation. Neurochemical Research. 23(12):1467-1476.  

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