PrP Peptide High Resolution Structural Analysis

Michael Baldwin, PhD
University of California, San Franc (San Francisco, CA)
Year Awarded:
1994
Grant Duration:
April 1, 1994 to March 31, 1996
Disease:
Alzheimer's Disease
Award Amount:
$199,240
Grant Reference ID:
A1994078
Award Type:
Standard
Award Region:
US Southwestern

PrP Peptide High Resolution Structural Analysis

Details


Publications

Zhang, H., Stockel, J., Mehlhorn, I., Groth, D., et al. (1997) Physical studies of conformational plasticity in a recombinant prion protein. Biochemistry. 36(12): 3543-3553.  

Heller, J., Kolbert, A.C., Larsen, R., Ernst, M., et al. (1996) Solid state NMR studies of the prion protein Hl fragment. Protein Sci. 5(8):1655-1661.  

[Book Chapter] Baldwin, M.A., Cohen, F.C., and Prusiner, S.B. (1996) Conformational change in the prion protein can be modeled by peptides. In: Subacute Transmissible Spongifom, Encephalopathies: Prion Diseases. Court, L., Dodet, B., eds. Elsevier, Paris, 1996, pp.315-322. Nguyen, J., Baldwin, M.A., Cohen, F.E., and Prusiner, S.B. (1995) Prion protein peptides induce alpha-helix to beta-sheet conformational transitions. Biochemistry. 34(13):4186-4192.  

Nguyen, J.T., Inouye, H., Baldwin, M.A., Fletterick, M.A., et al (1995) X-ray diffraction of scrapie prion rods and PrP peptides. J. Mol. Biol. 252(4):412-422.  

[Book Chapter] Baldwin, M.A., Zhang, H., Bekker, T., Zho, S., et al. Synthetic peptides model alpha-helix to Beta-sheet conformational changes in the prion protein. In: Peptides: chemistry, structure and biology. Kaumaya, P.T.P. and Hodges, R.S., eds. ESCOM, Leiden, 1995, pp.468-470. [Book Chapter] In: Peptides. Maia, H.L.S., ed., ESCOM, Leiden, (1994) pp.580-581. [Book Chapter] Baldwin, M.A. and Prusiner, S.B. Molecular biology, genetics and protein chemistry of prion diseases. In: Recent Advances in Alzheimer's Disease and Related Disorders. K. Iqbal, J.A. Mortimer, B. Winblad, and H. Wisniewski, eds. Wiley, 1995, pp.757-773. Zhang, H., Kaneko, K., Nguyen, J.T., Livshits, T.L., et al. (1995) Conformational transitions in peptides containing two putative alpha-helices of the prion protein. J. Mol. Biol. 250(4):514-526.  

Baldwin, M.A., Pan, K. M., Nguyen, J., Gasset, M., et al. (1994) Spectroscopic characterization of conformational differences between PrPC and PrPSc: an alpha-helix to beta-sheet transition. Philos. Trans. Roy. Soc. Lond. B Biol Sci. 343(1306):435-441.  

[Book Chapter] Baldwin, M.A., Nguyen, J., Zhang, H., Livshits, T., et al. (1994) Conformational changes in the prion protein can be simulated with synthetic peptides. In: Peptides. Maia, H.L.S., ed., ESCOM, Leiden, pp.580-581.

Cohen, F.E., Pan, K.M., Huang, Z., Baldwin, M., et al. (1994) Structural clues to prion replication. Science. 264:530-531.  

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