Protein Modification in Alzheimer Disease

Mark Smith, PhD
Case Western Reserve University (Cleveland, OH)
Year Awarded:
Grant Duration:
April 1, 1995 to March 31, 1997
Alzheimer's Disease
Award Amount:
Grant Reference ID:
Award Type:
Award Region:
US Midwestern

In Memory of Dr. Mark A. Smith

Protein Modification in Alzheimer Disease




[Book Chapter] Smith, M.A., Sayre, L.M., and Perry, G. 'Primary Involvement of Oxidative Damage and Redox Imbalance in Alzheimer and Other Neurodegenerative Diseases.' In: Redox Regulation of Cell Signaling and Its Clinical Application. Chapter 10, pp. 115-126. Marcel Dekker, Inc. 1999. Smith, M.A., Wehr, K., Harris, P.L., Siedlak, S.L., Connor, J.R., and Perry, G. (1998) Abnormal localization of iron regulatory protein in Alzheimer's disease. Brain Research. 788(1-2):232-236.  

Smith, M.A., Hirai, K., Hsiao, K., Papolla, M.A., Harris, P.L., Siedlak, S.L., Tabaton, M., and Perry, G. (1998) Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress. Journal of Neurochemistry. 70:2212-2215.  

[PMID:nd] Smith, M.A., Sayre, L.M., Anderson, V.E., Harris, P.L.R., Beal, M.F., Kowall, N., and Perry, G. (1998) Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine. The Journal of Histochemistry & Cytochemistry. 46(6):731-735.[link not available] Castellani, R. J., Perry, G., Harris, P.L.R., Cohen, M.L., Sayre, L.M., Salomon, R.G., Smith, M.A. (1998) Advanced Lipid peroxidation end-products in Alzheimer's disease. Brain Research. 787:15-18.  

[Book Chapter] Smith, M.A., Sayre, L.M., and Perry, G. Neurogerontology and Neurogeriatrics 2:Inflammation and Neuroimmunotrophic Activity in Alzheimer's Disease, In: Cacabelos R. Winblad B., Eikelenboom P, Eds. Prous Science Publishers, 1998, pp. 57-62. [Book Chapter] Smith, M.A. 'Alzheimer's Disease'. In: International Review of Neurobiology. Volume 42, p. 1-54. Academic Press, 1998. [Book Chapter] Perry, G. and Smith, M.A. 'Oxidative Damage: An Early and Central Event in the Pathogenesis of Alzheimer Disease'. In: Progress in HPLC-HPCE, Vol. 7, pp. 93-110. G. Ali Qureshi et. al. 1998. [Book Chapter] Perry, G. and Smith, M.A. 'Neuronal Oxidative Stress is a common feature of Alzheimer's and Parkinson's diseases'. In: Progress in Alzheimer's and Parkinson's Diseases. Chapter 12, pp.77-126. Plenum Press, New York, 1998. Perry, G. and Smith, M.A. (1998) Is oxidative damage central to the pathogenesis of Alzheimer's disease?' Acta Neurol. Belg. 98(2):175-179.  

Sayre, L.M., Zelasko, D.A., Harris, P.L.R., Perry, G., et al. (1997) 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. J. Neurochem. 68:2092-2097.


Smith, M.A., Harris, P.L.R., Sayre, L.M., Beckman, J.S., and Perry, G. (1997) Widespread peroxynitrite-mediated damage in Alzheimer's disease. J. Neurosci. 17:2653-2657.  

Smith, M.A., Nagaraj, R.H., and Perry, G. (1997) Protocol for the quantitative analysis of paired helical filament solubilization: a method applicable to insoluble amyloids and inclusion bodies. Brain Res. Protocols, 1(3):247-52.  

McShea, A., Harris, P.L.R., Webster, K.R., Wahl, A.F., and Smith, M.A. (1997) Abnormal expression of the cell cycle regulators P16 and CDK 4 in Alzheimer's disease. American Journal of Pathology. 150(6):1933-1939.  

Castellani, R.J., Perry, G., Harris, P.L.R., Monnier, V.M., Cohen, M.L., and Smith, M.A. (1997) Advanced glycation modification of Rosenthal fibers in patients with Alexander Disease. Neuroscience Letters. 231:79-82.  

Smith, M.A., Harris, P.L.R., Sayre, L.M., and Perry, G. (1997) Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proc. Natl. Acad. Sci. USA. 94(18):9866-9868.  

[Book Chapter] Smith, M.A., Sayre, L.M. and Perry, G. Morphological Aspects of Oxidative Damage in Alzheimer's Disease. In: Mitochondria and Free Radicals in Neurodegenerative Diseases, Chapter 16, 1997 Wiley-Liss, Inc., p. 335-341 Smith, M.A., Dunbar, C.E., Miller, E.J., and Perry, G. (1996) Trypsin interaction with senile plaques of Alzheimer's disease is mediated by beta-protein precursor. Mol .Chem. Neuropathol. 27(2):145-154.


Praprotnik, D., Smith, M.A., Richey, P.L., Vinters, H.V., and Perry, G. (1996) Filament heterogeneity within the dystrophic neurites of senile plaques suggests blockage of fast axonal transport in Alzheimer's disease. Acta Neuropathol. 91:226-235.  

Castellani, R., Smith, M.A., Richey, P.L., and Perry, G. (1996) Glycoxidation and oxidative stress in Parkinson disease and diffuse Lewy body disease. Brain Res. 737:195-200.  

[PMID:nd] Praprotnik, D., Smith, M.A., Richey, P.L., Vinters, H.V., and Perry, G. (1995) Plasma membrane fragility in dystrophic neurites in senile plaques of Alzheimer's disease: an index of oxidative stress. Acta Neuropathol. (Berl.) 91(1):1-5.[link not available]


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