Proteasome Inhibition in Alzheimer's Disease

Jeffrey Keller, PhD
University of Kentucky (Lexington, KY)
Year Awarded:
2000
Grant Duration:
April 1, 2000 to March 31, 2002
Disease:
Alzheimer's Disease
Award Amount:
$100,000
Grant Reference ID:
A2000009
Award Type:
Standard
Award Region:
US Southeastern

Proteasome Inhibition in Alzheimer's Disease

Details


Although it is clear that increased oxidative damage occurs in AD-affected brains, the mechanism(s) responsible for increasing oxidative stress is still unknown. Dr. Keller has recently found that the formation of a specialized assembly of enzymes known as the multicatalytic proteasome (MCP) is inhibited in AD brains, and that this inhibition leads to oxidative damage and neuron death. Because the MCP is normally involved in breaking down and recycling proteins, it serves important cellular functions. Dr. Keller is focusing on testing the hypothesis that oxidative stress causes inhibition of the MCP, and that MCP inhibition causes the accumulation of oxidized protein and damaged DNA.

Publications

Ding, Q. and Keller, J.N. (2001) Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins. J. Neurochem. 77(4):1010-1017.  

Don't miss out.
Receive research updates, inspiring stories, and expert advice
Please enter your first name.
Please enter your last name.
Keep me informed about: *
Please select at least one.
You must select at least one disease category.