Process of BetaSheet Assembly in Prion Hydrophobic Core

Daniel Kirschner, PhD
Boston College, Office of Research (Chestnut Hill, MA)
Year Awarded:
1998
Grant Duration:
April 1, 1998 to March 31, 2000
Disease:
Alzheimer's Disease
Award Amount:
$199,940
Grant Reference ID:
A1998004
Award Type:
Standard
Award Region:
US Northeastern

Process of BetaSheet Assembly in Prion Hydrophobic Core

Summary

Process of BetaSheet Assembly in Prion Hydrophobic Core

Publications

Inouye H, Kirschner DA (2000) ABeta fibrillogenesis: Kinetic parameters for fiber formation from Congo red binding. J. Struc. Biol. 130: 123-129.  

Lim A, Makhov AM, Bond J, Inouye H, Connors LH, Griffith JD, Kirschner DA, Costello CE, Erickson BW (2000) Betabellins 15D and 16D, de novo designed Beta sandwich proteins that have amyloidogenic properties. J. Struc. Biol. 130: 363-370.  

Inouye H, Bond J, Baldwin MA, Ball HL, Prusiner SB, Kirschner DA (2000) Structural changes in a hydrophobic domain of the prion protein induced by hydration and by Ala?Val and Pro?Leu substitutions. Journal of Molecular Biology 300: 1285-1298.  

Inouye H, Nguyen JT, Fraser PE, Shinchuk L, Packard AB, Kirschner DA (2000) Histidine residues underlie Congo red binding to ABeta analogs. Amyloid: Internat. J. of Experimental & Clinical Investig. 7: 179-188.  

Inouye H, Bond JE, Deverin SP, Lim A, Costello CE,. Kirschner DA (2002) Molecular organization of amyloid protofilament-like assembly of betabellin 15D: Helical array of Beta-sandwiches. Biophysical Journal 83:1716-1727.  

Bond JP, Deverin SP, Inouye H, El-Agnaf OMA, Teeter, MM, Kirschner DA (2003) Assemblies of Alzheimer's peptides ABeta(25-35) and ABeta(31-35): Reverse Beta-turn conformation and side chain interactions revealed by x-ray diffraction. Journal of Structural Biology 141:156-170.  

Inouye H, Kirschner DA (2003) X-ray fibre diffraction analysis of assemblies formed by prion-related peptides: Polymorphism of the heterodimer interface between PrPC and PrPSc. Fibre Diffraction Rev. 11:102- 112. [http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.521.2172&rep=rep1&type=pdf]

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