Prion Protein Polymorphisms Modulating Brain Degeneration

David Westaway, PhD
University of Toronto (Toronto, ON Canada)
Year Awarded:
1988
Grant Duration:
April 1, 1988 to March 31, 1990
Disease:
Alzheimer's Disease
Award Amount:
$186,600
Grant Reference ID:
A1988062
Award Type:
Standard
Award Region:
US Southwestern

Prion Protein Polymorphisms Modulating Brain Degeneration

Publications

Raleigh, E.A., Murray, N.E., Revel, H., Blumenthal, R.M., et al. (1988) McrA and McrB restriction phenotypes of some E. coli strains and implications for gene cloning. Nucleic Acids Res. 16:1563-1575. PubMed Icon Google Scholar Icon

Hsiao, K., Baker, H.F., Crow, T.J., Poulter, M., Owen, F., et al. (1989) Linkage of a prion protein missense variant to Gerstmann-Straussler syndrome. Nature. 338(6213):342-345. PubMed Icon Google Scholar Icon

Westaway, D., Carlson, G.A., and Prusiner, S.B. (1989) Unraveling prion diseases through molecular genetics. Trends Neurosci. 12:221-227. PubMed Icon Google Scholar Icon

[Book Chapter] Carlson, G.A., Westaway, D., Goodman, P.A., Kingsbury, D T., and Prusiner, S.B. Genetic control of scrapie incubation period in mice. In: Unconventional Virus Diseases of the Central Nervous System, Court, L.A., Dormont, D., Brown, P., Kingsbury, D.T., eds. L'Imprimerie Lefrancq et Cie, Cand., France, 1989, pp. 436-445.

[Book Chapter] Gabizon, R., McKinley, M.P., Groth, D., Westaway, D., et al. Immunoaffinity purification and neutralization of scrapie prions. In: Alzheimer's Disease and Related Disorders, K. Iqbal, H. Wisniewski, and B. Winblad, eds. Alan R. Liss, New York, 1989, pp. 583-600.

Scott, M., Foster, D., Mirenda, C., Serban, D., et al. (1989) Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques. Cell. 59:847-857. PubMed Icon Google Scholar Icon

Carlson, G.A., Westaway, D., DeArmond, S.J., Peterson-Torchia, M., and Prusiner, S.B. (1989) Primary structure of prion protein may modify scrapie isolate properties. Proc. Natl. Acad. Sci. USA. 86:7475-7479. PubMed Icon Google Scholar Icon

Carlson, G.A., Goodman, P.A., Lovett, M., Taylor, B.A., et al. (1988) Genetics and polymorphism of the mouse prion gene complex: the control of scrapie incubation time. Mol. Cell. Biol. 8:5528-5540. PubMed Icon Google Scholar Icon

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