Physiologic Relevance of ApoE Association with ABeta and Tau

Godfrey Getz, MD, PhD
The University of Chicago (Chicago, IL)
Year Awarded:
1995
Grant Duration:
April 1, 1995 to March 31, 1997
Disease:
Alzheimer's Disease
Award Amount:
$180,000
Grant Reference ID:
A1995100
Award Type:
Standard
Award Region:
US Midwestern

Physiologic Relevance of ApoE Association with ABeta and Tau

Details


Publications

LaDu, M.J., Lukens, J.R., Reardon, C.A., and Getz, G.S. (1997) Association of human, rat and rabbit apolipoprotein E with beta-amyloid. J. Neurosci. Res. 49(1):9-18.  

Puttfarcken, P.S., Manelli, A.M., Falduto, M.T., Getz, G.S., and LaDu, M.J. (1997) Effects of apolipoprotein E on neurite outgrowth and beta-amyloid-induced toxicity in developing rat primary hippocampal cultures. J. Neurochem. 68(2):760-769.  

[Book Chapter] Falduto, M.T. and LaDu, M.J. (1997) Role of apolipoprotein E in neurobiology and the pathogenesis of Alzheimer's disease. In: Alzheimer's Disease, J.D. Brioni, and M.W. Decker, eds. Wiley Press, New York.

Metzger, R.E., LaDu, M.J., Frail, D.E., Pan, J.B., et al. (1996) Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: implications for Alzheimer's disease. J. Neuropathol. Exp. Neurol. 55(3):372-380.  

Praprotnik, D., Smith, M.A., Richey, P.L., Vinters, H.V., and Perry, G. (1996) Plasma membrane fragility in dystrophic neurites in senile plaques of Alzheimer's disease: an index of oxidative stress. Acta Neuropathol. 91:1-5.  

LaDu, M.J., Pederson, T.M., Frail, D.E., Reardon, C.A., et al. (1995) Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloid. J. Biol. Chem. 270(16):9039-9042.  

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