The chemistry of Alzheimer's disease

Paul Axelsen, MD
University of Pennsylvania (Philadelphia, PA)
Year Awarded:
2008
Grant Duration:
April 1, 2008 to September 30, 2010
Disease:
Alzheimer's Disease
Award Amount:
$187,500
Grant Reference ID:
A2008123
Award Type:
Pilot
Award Region:
US Northeastern
Paul Axelsen, MD

Oxidative stress and amyloidogenesis

Summary

Oxidative stress and amyloid fibril formation are consistent major themes among processes thought to be involved in the pathogenesis of Alzheimer's disease. However, a mechanistic link between these two processes has not been defined. The research being proposed will probe human brain tissues and animal models of Alzheimer's disease for evidence of a specific chemical mechanism that will be amenable to therapeutic intervention.

Details

Oxidative stress and amyloid fibril formation are consistent major themes among processes thought to be involved in the pathogenesis of Alzheimer's disease. However, a mechanistic link between these two processes has not been defined. The research being proposed will probe human brain tissues and animal models of Alzheimer's disease for evidence of a specific chemical mechanism that will be amenable to therapeutic intervention.
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