Oxidative mechanisms of amyloid initiation

Ian Murray, PhD
University of Pennsylvania (Philadelphia, PA)
Year Awarded:
2004
Grant Duration:
April 1, 2004 to March 31, 2006
Disease:
Alzheimer's Disease
Award Amount:
$100,000
Grant Reference ID:
A2004248
Award Type:
Standard
Award Region:
US Northeastern

Oxidative mechanisms of amyloid initiation

Details


Patients with Alzheimer's disease experience a gradual loss of memory, problems with reasoning, disorientation, loss of language skills, and behavioral problems. The major cause of the disease is thought to be the misfolding of a specific protein within the brain. Many researchers hypothesize that oxidation and free radical damage to the brain predates the protein misfolding and the clumping of protein fragments into plaques. Dr. Murray is investigating the interactions of oxidation and free radical damage with the brain lipids and misfolded proteins. It is hoped that the resulting knowledge will assist in the development of new treatment methods for Alzheimer's and possibly other neurodegenerative diseases.

Publications

Murray, I.V., Sindoni, M.E., and Axelsen, P.H. (2005) Promotion of oxidativelipid membrane damage by amyloid beta proteins. Biochemistry. 44(37):12606-12613.  

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