NMR studies of ganglioside and AB peptide interactions

Pravat Mandal, PhD
University of Pittsburgh (Pittsburgh, PA)
Year Awarded:
2004
Grant Duration:
April 1, 2004 to March 31, 2006
Disease:
Alzheimer's Disease
Award Amount:
$100,000
Grant Reference ID:
A2004267
Award Type:
Standard
Award Region:
US Northeastern

NMR studies of ganglioside and AB peptide interactions

Details


Amyloid plaques and tangled bundles of fiber (neurofibrillary tangles or NFTs) are thought to play an important role in the pathogenesis of Alzheimer's disease (AD). Scientists have found that the amyloid plaques are associated with a type of molecule called gangliosides in the brains of Alzheimer's patients. There are five main gangliosides in the human brain, and research shows that some gangliosides increase while others decrease with aging. Dr. Mandal has already demonstrated through nuclear magnetic resonance (NMR) studies that one ganglioside is capable of preventing the toxic precipitant in an experimental environment. His current goal is to understand the role of these “good” and “bad” gangliosides in the formation of toxic amyloid plaques. This research could lead to the design of new drugs that could slow or halt the symptoms of AD and could also contribute to the development of a noninvasive way to test for Alzheimer's disease using magnetic resonance spectroscopy.

Publications

Mandal, P. K., McClure, R.J., Pettegrew, J.W. (2004) Interactions of Abeta(1-40) with glycerophosphocholine and intact erythrocyte membranes: fluorescenceand circular dichroism studies. Neurochemical Research. 29(12):2273-2279.  

Mandal, P.K. and Pettegrew, J.W. (2004) Alzheimer's disease: soluble oligomeric Abeta(1-40) peptide in membrane mimic environment from solution NMR and circular dichroism studies. Neurochemical Research. 29(12):2267-2272.  

Mandal, P.K., McClure, R.J., Panchalingam, K., and Pettegrew, J.W. (2004)Ganglioside and amyloid peptide interaction studies in PBS medium. Biophysical Journal. 86:340. [PMID:nd][link not available]

Mandal, P.K. and Pettegrew, J.W. (2004) Alzheimer's disease: soluble oligomeric AB (1-40) peptide in membrane mimic environment from solution NMR and circular dichroism studies. Platform Presentation. Society for Neuroscience, San Diego. [conference abstract]

Pettegrew, J.W., Mandal, P.K., McClure, R.J., Panchalingam, K. (2004) Structure and dynamics studies of AB (1-40) peptide in different environments from solution NMR. Platform Presentation. Society for Neuroscience, San Diego [conference abstract]

Mandal, P.K. and Pettegrew, J.W. (2004) Alzheimer's disease: soluble oligo circular dichroism studies. Platform Presentation. International Conference on AD. (Hot Topic Category).[conference abstract]

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