Modifiers of Abeta toxicity in Drosophila

Mary Konsolaki, PhD
Rutgers, The State University of NJ (Piscataway, NJ)
Year Awarded:
Grant Duration:
April 1, 2005 to March 31, 2007
Alzheimer's Disease
Award Amount:
Grant Reference ID:
Award Type:
Award Region:
US Northeastern

Modifiers of Abeta toxicity in Drosophila


Although progress has been made in understanding the basic pathology of Alzheimer's disease, the currently available therapies can only address the symptoms of the disease and fail to reverse its causes. In order to be able to design therapies that effectively combat this devastating disease, it is necessary to gain a better understanding of the mechanisms that lead to neuronal death in affected individuals. Aβ peptides have been shown to be toxic to neurons, but the specific mechanisms of such toxicity remain to be further elucidated. Dr. Konosolaki intends to isolate and characterize genes that play a role in Aβ-associated toxicity, using genetic screens in flies. These screens will lead to the identification of novel factors associated with Aβ neurotoxicity and will contribute to the understanding of pathways that mediate Aβ effects. This knowledge may contribute to future design of appropriate therapies for Alzheimer's.


Cao, W., Song, H-J., Gangi, T., Kelkar, A., Antani, I., Garza, D., and Konsolaki, M. (2008). Identification of novel genes that modify phenotypes induced by Alzheimer's beta amyloid overexpression in Drosophila. Genetics 178(3):1457-71.  

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