Project DetailsTherapies using your own (self‐derived) bone marrow cells have promise for treating many different diseases, including Alzheimer's disease. This type of self‐recognizing stem cell therapy has an increased chance of success, because one can avoid the pesky problem of the immune system labeling the cells as foreign invaders and killing them before they have a chance to work. Dr. Biju Chandu and collaborators will be testing a new bone marrow cell treatment for Alzheimer's disease. First, they will isolate white blood cells that roam freely in the easily-accessible blood vessels. These cells will in turn be genetically modified to become bone marrow cells and re-purposed to release anti-Alzheimer's disease drugs. The modified cells are injected back in the blood stream, where they migrate to the parts of the brain that require treatment. After this new treatment is tested in cell culture and animals in this project, the researchers may then decide to move this technique into human clinical trials.